Microvascular Invasion in Small-sized Hepatocellular Carcinoma: Significance for Outcomes Following Hepatectomy and Radiofrequency Ablation

The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent factors related to the...

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Bibliographic Details
Published in:Anticancer research 2018-02, Vol.38 (2), p.1053-1060
Main Authors: Imai, Katsunori, Yamashita, Yo-Ichi, Yusa, Toshihiko, Nakao, Yosuke, Itoyama, Rumi, Nakagawa, Shigeki, Okabe, Hirohisa, Chikamoto, Akira, Ishiko, Takatoshi, Baba, Hideo
Format: Article
Language:English
Subjects:
Ablation
Disease control
Hepatectomy
Hepatocellular carcinoma
Liver cancer
Mathematical models
Microvasculature
Multivariate analysis
Patients
Prothrombin
Radio frequency
Radiofrequency ablation
Risk analysis
Risk factors
Survival
Tumors
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Summary:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent factors related to the presence of MVI. The predictive model was applied to 159 patients who underwent RFA, and their outcomes were examined. A multivariate analysis revealed that α-fetoprotein ≥15 ng/ml (relative risk (RR) 3.05, p=0.02), des-γ-carboxy prothrombin ≥100 mAU/ml (RR 4.19, p=0.003), and tumor size ≥2 cm (RR 3.37, p=0.03) were independent risk factors of MVI. Among the patients who underwent RFA, the survival in patients with risk factors 2-3 was significantly worse, and local recurrence was more frequently obserbed than those with 0-1. When an HCC tumor is expected to display MVI, RFA may not be suitable in terms of poorer survival and local disease-control rates.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.12322