The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model

Purpose We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects. Methods Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on...

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Bibliographic Details
Published in:Child's nervous system 2018-05, Vol.34 (5), p.933-938
Main Authors: Kantarcioglu, Emrah, Kahilogullari, Gokmen, Zaimoglu, Murat, Atmis, Esin Ozlem, Peker, Elif, Yigman, Zeynep, Billur, Deniz, Aydin, Sevim, Erden, Ilhan Memet, Unlü, Agahan
Format: Article
Language:English
Subjects:
Animals
Chick Embryo - radiation effects
Disease Models, Animal
Dose-Response Relationship, Radiation
Embryonic Development - radiation effects
Magnetic Fields - adverse effects
Magnetic Resonance Imaging - adverse effects
Medicine
Medicine & Public Health
Neural Tube - diagnostic imaging
Neural Tube - embryology
Neural Tube - radiation effects
Neural Tube Defects - diagnostic imaging
Neural Tube Defects - etiology
Neurosciences
Neurosurgery
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Summary:Purpose We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects. Methods Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. “The new technique” was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage. Results Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields ( p  
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-018-3734-9