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The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model
Purpose We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects. Methods Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on...
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| Published in: | Child's nervous system 2018-05, Vol.34 (5), p.933-938 |
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| container_issue | 5 |
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| container_title | Child's nervous system |
| container_volume | 34 |
| creator | Kantarcioglu, Emrah Kahilogullari, Gokmen Zaimoglu, Murat Atmis, Esin Ozlem Peker, Elif Yigman, Zeynep Billur, Deniz Aydin, Sevim Erden, Ilhan Memet Unlü, Agahan |
| description | Purpose
We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects.
Methods
Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. “The new technique” was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage.
Results
Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields (
p
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| doi_str_mv | 10.1007/s00381-018-3734-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1993996456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1993996456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-d4a3bee425b9dbb774fbf28d86d8263cb7891f6718cd996bcfd17f5bd845d62d3</originalsourceid><addsrcrecordid>eNp9kDtPxDAQhC0EguPgB9AglzQBv5LYJUK8JCSao7Zie30EEvuwE6T79xgdUFKtdndmpPkQOqPkkhLSXmVCuKQVobLiLReV2kMLKjivCK_JPloQVjdVSwQ5Qsc5vxFCa8nUITpiiismGF0gt3oFDN6DnXD0eOzWAabe4gQ5hi5YwH259WGNY8AB5tQNeJoNYAefMMTNCGHCfcBdwNClYYvta2_foWyjSduIx-hgOEEHvhsynP7MJXq5u13dPFRPz_ePN9dPleVCTJUTHTcAgtVGOWPaVnjjmXSycZI13JpWKuqblkrrlGqM9Y62vjZOito1zPElutjlblL8mCFPeuyzhWHoAsQ5a6pKb9WIuilSupPaFHNO4PUmlaZpqynR33D1Dq4ucPU3XK2K5_wnfjYjuD_HL80iYDtBLq-whqTf4pxCqfxP6hcZ94X-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993996456</pqid></control><display><type>article</type><title>The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model</title><source>Springer Nature</source><creator>Kantarcioglu, Emrah ; Kahilogullari, Gokmen ; Zaimoglu, Murat ; Atmis, Esin Ozlem ; Peker, Elif ; Yigman, Zeynep ; Billur, Deniz ; Aydin, Sevim ; Erden, Ilhan Memet ; Unlü, Agahan</creator><creatorcontrib>Kantarcioglu, Emrah ; Kahilogullari, Gokmen ; Zaimoglu, Murat ; Atmis, Esin Ozlem ; Peker, Elif ; Yigman, Zeynep ; Billur, Deniz ; Aydin, Sevim ; Erden, Ilhan Memet ; Unlü, Agahan</creatorcontrib><description>Purpose
We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects.
Methods
Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. “The new technique” was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage.
Results
Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields (
p
< 0.05). However, although the incidence of neural tube closure defects was expected to increase as exposure (tesla level) increased, we found a higher rate of defects in the 1.5-T group compared with the 3-T group. By contrast, the highest incidence of growth retardation was in the 3-T group, which was consistent with our expectation that growth retardation would be more likely as tesla level increased.
Conclusions
We therefore conclude that the use of magnetic resonance imaging as a diagnostic tool can result in midline closure defects and growth retardation in chicken embryos. We hypothesize that this may also be true for human embryos exposed to MRI. If a pregnant individual is to take an MRI scan, as for lumbar disc disease or any other any other reason, our results indicate that consideration should be given to an avoidance of MRI during pregnancy.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-018-3734-9</identifier><identifier>PMID: 29392421</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Chick Embryo - radiation effects ; Disease Models, Animal ; Dose-Response Relationship, Radiation ; Embryonic Development - radiation effects ; Magnetic Fields - adverse effects ; Magnetic Resonance Imaging - adverse effects ; Medicine ; Medicine & Public Health ; Neural Tube - diagnostic imaging ; Neural Tube - embryology ; Neural Tube - radiation effects ; Neural Tube Defects - diagnostic imaging ; Neural Tube Defects - etiology ; Neurosciences ; Neurosurgery ; Original Paper</subject><ispartof>Child's nervous system, 2018-05, Vol.34 (5), p.933-938</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-d4a3bee425b9dbb774fbf28d86d8263cb7891f6718cd996bcfd17f5bd845d62d3</citedby><cites>FETCH-LOGICAL-c344t-d4a3bee425b9dbb774fbf28d86d8263cb7891f6718cd996bcfd17f5bd845d62d3</cites><orcidid>0000-0001-8137-0510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29392421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kantarcioglu, Emrah</creatorcontrib><creatorcontrib>Kahilogullari, Gokmen</creatorcontrib><creatorcontrib>Zaimoglu, Murat</creatorcontrib><creatorcontrib>Atmis, Esin Ozlem</creatorcontrib><creatorcontrib>Peker, Elif</creatorcontrib><creatorcontrib>Yigman, Zeynep</creatorcontrib><creatorcontrib>Billur, Deniz</creatorcontrib><creatorcontrib>Aydin, Sevim</creatorcontrib><creatorcontrib>Erden, Ilhan Memet</creatorcontrib><creatorcontrib>Unlü, Agahan</creatorcontrib><title>The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects.
Methods
Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. “The new technique” was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage.
Results
Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields (
p
< 0.05). However, although the incidence of neural tube closure defects was expected to increase as exposure (tesla level) increased, we found a higher rate of defects in the 1.5-T group compared with the 3-T group. By contrast, the highest incidence of growth retardation was in the 3-T group, which was consistent with our expectation that growth retardation would be more likely as tesla level increased.
Conclusions
We therefore conclude that the use of magnetic resonance imaging as a diagnostic tool can result in midline closure defects and growth retardation in chicken embryos. We hypothesize that this may also be true for human embryos exposed to MRI. If a pregnant individual is to take an MRI scan, as for lumbar disc disease or any other any other reason, our results indicate that consideration should be given to an avoidance of MRI during pregnancy.</description><subject>Animals</subject><subject>Chick Embryo - radiation effects</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Embryonic Development - radiation effects</subject><subject>Magnetic Fields - adverse effects</subject><subject>Magnetic Resonance Imaging - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neural Tube - diagnostic imaging</subject><subject>Neural Tube - embryology</subject><subject>Neural Tube - radiation effects</subject><subject>Neural Tube Defects - diagnostic imaging</subject><subject>Neural Tube Defects - etiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Paper</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPxDAQhC0EguPgB9AglzQBv5LYJUK8JCSao7Zie30EEvuwE6T79xgdUFKtdndmpPkQOqPkkhLSXmVCuKQVobLiLReV2kMLKjivCK_JPloQVjdVSwQ5Qsc5vxFCa8nUITpiiismGF0gt3oFDN6DnXD0eOzWAabe4gQ5hi5YwH259WGNY8AB5tQNeJoNYAefMMTNCGHCfcBdwNClYYvta2_foWyjSduIx-hgOEEHvhsynP7MJXq5u13dPFRPz_ePN9dPleVCTJUTHTcAgtVGOWPaVnjjmXSycZI13JpWKuqblkrrlGqM9Y62vjZOito1zPElutjlblL8mCFPeuyzhWHoAsQ5a6pKb9WIuilSupPaFHNO4PUmlaZpqynR33D1Dq4ucPU3XK2K5_wnfjYjuD_HL80iYDtBLq-whqTf4pxCqfxP6hcZ94X-</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Kantarcioglu, Emrah</creator><creator>Kahilogullari, Gokmen</creator><creator>Zaimoglu, Murat</creator><creator>Atmis, Esin Ozlem</creator><creator>Peker, Elif</creator><creator>Yigman, Zeynep</creator><creator>Billur, Deniz</creator><creator>Aydin, Sevim</creator><creator>Erden, Ilhan Memet</creator><creator>Unlü, Agahan</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8137-0510</orcidid></search><sort><creationdate>20180501</creationdate><title>The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model</title><author>Kantarcioglu, Emrah ; Kahilogullari, Gokmen ; Zaimoglu, Murat ; Atmis, Esin Ozlem ; Peker, Elif ; Yigman, Zeynep ; Billur, Deniz ; Aydin, Sevim ; Erden, Ilhan Memet ; Unlü, Agahan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-d4a3bee425b9dbb774fbf28d86d8263cb7891f6718cd996bcfd17f5bd845d62d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Chick Embryo - radiation effects</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Embryonic Development - radiation effects</topic><topic>Magnetic Fields - adverse effects</topic><topic>Magnetic Resonance Imaging - adverse effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neural Tube - diagnostic imaging</topic><topic>Neural Tube - embryology</topic><topic>Neural Tube - radiation effects</topic><topic>Neural Tube Defects - diagnostic imaging</topic><topic>Neural Tube Defects - etiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kantarcioglu, Emrah</creatorcontrib><creatorcontrib>Kahilogullari, Gokmen</creatorcontrib><creatorcontrib>Zaimoglu, Murat</creatorcontrib><creatorcontrib>Atmis, Esin Ozlem</creatorcontrib><creatorcontrib>Peker, Elif</creatorcontrib><creatorcontrib>Yigman, Zeynep</creatorcontrib><creatorcontrib>Billur, Deniz</creatorcontrib><creatorcontrib>Aydin, Sevim</creatorcontrib><creatorcontrib>Erden, Ilhan Memet</creatorcontrib><creatorcontrib>Unlü, Agahan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kantarcioglu, Emrah</au><au>Kahilogullari, Gokmen</au><au>Zaimoglu, Murat</au><au>Atmis, Esin Ozlem</au><au>Peker, Elif</au><au>Yigman, Zeynep</au><au>Billur, Deniz</au><au>Aydin, Sevim</au><au>Erden, Ilhan Memet</au><au>Unlü, Agahan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>34</volume><issue>5</issue><spage>933</spage><epage>938</epage><pages>933-938</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Purpose
We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects.
Methods
Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. “The new technique” was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage.
Results
Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields (
p
< 0.05). However, although the incidence of neural tube closure defects was expected to increase as exposure (tesla level) increased, we found a higher rate of defects in the 1.5-T group compared with the 3-T group. By contrast, the highest incidence of growth retardation was in the 3-T group, which was consistent with our expectation that growth retardation would be more likely as tesla level increased.
Conclusions
We therefore conclude that the use of magnetic resonance imaging as a diagnostic tool can result in midline closure defects and growth retardation in chicken embryos. We hypothesize that this may also be true for human embryos exposed to MRI. If a pregnant individual is to take an MRI scan, as for lumbar disc disease or any other any other reason, our results indicate that consideration should be given to an avoidance of MRI during pregnancy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29392421</pmid><doi>10.1007/s00381-018-3734-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8137-0510</orcidid></addata></record> |
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| ispartof | Child's nervous system, 2018-05, Vol.34 (5), p.933-938 |
| issn | 0256-7040 1433-0350 |
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| source | Springer Nature |
| subjects | Animals Chick Embryo - radiation effects Disease Models, Animal Dose-Response Relationship, Radiation Embryonic Development - radiation effects Magnetic Fields - adverse effects Magnetic Resonance Imaging - adverse effects Medicine Medicine & Public Health Neural Tube - diagnostic imaging Neural Tube - embryology Neural Tube - radiation effects Neural Tube Defects - diagnostic imaging Neural Tube Defects - etiology Neurosciences Neurosurgery Original Paper |
| title | The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model |
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