Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia

Objective To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease. Methods This cross-sectional analytical study was conducted among children aged 1 to 12 years of age with moderate-to-severe iron deficiency anemia and control children...

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Bibliographic Details
Published in:Indian pediatrics 2018-01, Vol.55 (1), p.31-34
Main Authors: Narang, Manish, Natarajan, Ravikumar, Shah, Dheeraj, Puri, Amarender Singh, Manchanda, Vikas, Kotru, Mrinalini
Format: Article
Language:English
Subjects:
Anemia, Iron-Deficiency - complications
Anemia, Iron-Deficiency - epidemiology
Biopsy
Celiac Disease - complications
Celiac Disease - epidemiology
Celiac Disease - pathology
Child
Child, Preschool
Cross-Sectional Studies
Endoscopy, Gastrointestinal
Female
Humans
Immunoglobulin A - blood
Infant
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Research Paper
Transglutaminases - blood
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Summary:Objective To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease. Methods This cross-sectional analytical study was conducted among children aged 1 to 12 years of age with moderate-to-severe iron deficiency anemia and control children without anemia.Serum IgA-tissue trans-glutaminase levels were assessed in both cases and controls. All children with positive celiac serology underwent upper gastrointestinal endoscopy and duodenal biopsy; biopsy finding of Marsh grade 3 was considered positive for celiac disease. Results There were 152 anemic children and 152 controls with mean (SD) hemoglobinof 7.7 (1.8) and 12.2 (0.74) g/dL, respectively. 16 (10.5%) cases and 3 (2%) control patients had positive serology for celiac disease [OR (95% CI) 5.33 (1.52-18.67), P =0.007]. Six (3.9%) children with iron-deficiency anemia and none of the controls had biopsy features diagnostic of celiac disease. Conclusion In the Northern Indian tertiary-care hospital outpatient setting, Celiac disease was associated with 4% of children presenting with moderate-to-severe anemia.
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-018-1223-6