The correlation between cardiac magnetic resonance T2 and left ventricular global longitudinal strain in people with β‐thalassemia

• Published in: Echocardiography (Mount Kisco, N.Y.) N.Y.), 2018-04, Vol.35 (4), p.438-444
• Main Authors: Parsaee, Mozhgan, Akiash, Nehzat, Azarkeivan, Azita, Alizadeh Sani, Zahra, Amin, Ahmad, Pazoki, Mahboubeh, Samiei, Niloufar, Jalili, Mohammad Ali, Adel, Mohammad Hassan, Rezaian, Nahid
• Format: Article
• Language: English
• Subjects: cardiac magnetic resonance imaging; left ventricular functionthalassemia; strain and tissue Doppler echocardiography
• ISSN: 0742-2822; 1540-8175
• DOI: 10.1111/echo.13801

Background Heart failure is the biggest cause of mortality and morbidity in people with thalassemia, and iron deposition in cardiac tissue impairs cardiovascular function. Therefore, early detection of cardiac involvement is important to improve the prognosis in these individuals. Method Two‐ and three‐dimensional echocardiography was performed to evaluate left ventricular ejection fraction (LVEF), left ventricular volumes and diameters, and global longitudinal strain (GLS) in 130 individuals with β‐thalassemia using the speckle tracking method. Magnetic resonance imaging (MRI) was carried out on both the heart and liver. The participants were divided into 2 groups based on cardiac T2* values (normal and abnormal cardiac iron load), and the correlation between cardiac T2* MRI and GLS was evaluated. Results The statistical analysis showed a significant correlation between cardiac T2* MRI and left ventricular global longitudinal strain. There was a significant difference in global longitudinal strain (P