Aspirin does not prevent growth of vestibular schwannomas: A case‐control study

Objectives/Hypothesis To determine if aspirin intake is associated with reduced growth of vestibular schwannomas (VS). To determine the prevalence of contraindications to regular aspirin in patients with VS. Study Design Retrospective, observational case‐control study. Methods The study utilized a p...

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Bibliographic Details
Published in:The Laryngoscope 2018-09, Vol.128 (9), p.2139-2144
Main Authors: MacKeith, Samuel, Wasson, Joseph, Baker, Charlotte, Guilfoyle, Matthew, John, Deepa, Donnelly, Neil, Mannion, Richard, Jefferies, Sarah, Axon, Patrick, Tysome, James R.
Format: Article
Language:English
Subjects:
Acoustic neuroma
Aged
Aspirin
Aspirin - therapeutic use
Brain cancer
Case-Control Studies
Cyclooxygenase Inhibitors - therapeutic use
Disease Progression
Female
growth
Humans
Logistic Models
Magnetic Resonance Imaging
Male
Neuroma, Acoustic - diagnostic imaging
Neuroma, Acoustic - drug therapy
NMR
Nuclear magnetic resonance
Propensity Score
Retrospective Studies
Treatment Outcome
Tumors
vestibular schwannomas
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Summary:Objectives/Hypothesis To determine if aspirin intake is associated with reduced growth of vestibular schwannomas (VS). To determine the prevalence of contraindications to regular aspirin in patients with VS. Study Design Retrospective, observational case‐control study. Methods The study utilized a postal questionnaire and telephone interviews to determine aspirin exposure. Propensity score matching was used to control for age, sex, and tumor size. Cases were defined as patients with VS proven to have grown on serial magnetic resonance imaging (MRI). Controls were defined as patient with VS stable on serial MRI. Prevalence of regular aspirin use was compared in patients with growing VS versus stable VS. Absolute and relative contraindications to aspirin intake were recorded. Results Six hundred fifty‐three patients with VS were contacted, and responses were received by 67% (220 cases and 217 controls). The mean tumor size was 11.3 mm (9.0 mm and 13.3 mm in controls and cases, respectively). Aspirin exposure was more common in stable VS than growing VS (22.1% vs. 17.3%). However, following matching to control for covariates, aspirin was not found to be associated with VS stability (P = .475). Multiple logistic regression (analysis of variance) found tumor size to be the only factor strongly associated with tumor growth (P 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.27114