Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four-Component Reaction

Route finder: The Passerini three‐component reaction of a carboxylic acid, an aldehyde (or ketone), and an isocyanide to give an α‐acyloxycarboxamide actually follows a four‐component mechanism involving an additional molecule of carboxylic acid (see scheme). The discovery was made by applying a new...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-01, Vol.50 (3), p.644-649
Main Authors: Maeda, Satoshi, Komagawa, Shinsuke, Uchiyama, Masanobu, Morokuma, Keiji
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Amides - chemical synthesis
Amides - chemistry
Carboxylic Acids - chemistry
Cyanides - chemistry
density functional calculations
Ketones - chemistry
multicomponent reactions
Passerini reaction
reaction mechanisms
transition states
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