The Genetic Makeup of the Drosophila piRNA Pathway

The piRNA (PIWI-interacting RNA) pathway is a small RNA silencing system that acts in animal gonads and protects the genome against the deleterious influence of transposons. A major bottleneck in the field is the lack of comprehensive knowledge of the factors and molecular processes that constitute...

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Bibliographic Details
Published in:Molecular cell 2013-06, Vol.50 (5), p.762-777
Main Authors: Handler, Dominik, Meixner, Katharina, Pizka, Manfred, Lauss, Kathrin, Schmied, Christopher, Gruber, Franz Sebastian, Brennecke, Julius
Format: Article
Language:English
Subjects:
animal ovaries
Animals
Animals, Genetically Modified
biogenesis
Chromatin
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Endoribonucleases - genetics
Endoribonucleases - metabolism
Female
Gene Expression Regulation
genes
germ cells
insects
metabolism
Mitochondria - metabolism
nuclear membrane
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Ovary - physiology
Resource
RNA Helicases - genetics
RNA Helicases - metabolism
RNA Interference
RNA transport
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
RNA-Binding Proteins
Sensitivity and Specificity
small interfering RNA
transposons
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