Parsing the Interferon Transcriptional Network and Its Disease Associations

Type 1 interferon (IFN) is a key mediator of organismal responses to pathogens, eliciting prototypical “interferon signature genes” that encode antiviral and inflammatory mediators. For a global view of IFN signatures and regulatory pathways, we performed gene expression and chromatin analyses of th...

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Bibliographic Details
Published in:	Cell 2016-01, Vol.164 (3), p.564-578
Main Authors:	Mostafavi, Sara, Yoshida, Hideyuki, Moodley, Devapregasan, LeBoité, Hugo, Rothamel, Katherine, Raj, Towfique, Ye, Chun Jimmie, Chevrier, Nicolas, Zhang, Shen-Ying, Feng, Ting, Lee, Mark, Casanova, Jean-Laurent, Clark, James D., Hegen, Martin, Telliez, Jean-Baptiste, Hacohen, Nir, De Jager, Philip L., Regev, Aviv, Mathis, Diane, Benoist, Christophe
Format:	Article
Language:	English
Subjects:	ancestry Animals CD4-Positive T-Lymphocytes - metabolism chromatin data collection Datasets as Topic DNA gene expression Gene Regulatory Networks genes genetic techniques and protocols human diseases Humans Interferon Type I - immunology Interferon Type I - metabolism interferons Janus Kinases - metabolism Mice Mice, Inbred C57BL pathogens pharmacology Receptor, Interferon alpha-beta - metabolism transcription (genetics)
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