Computational identification of potential transcriptional regulators of TGF-ß1 in human atherosclerotic arteries

TGF-ß is protective in atherosclerosis but deleterious in metastatic cancers. Our aim was to determine whether TGF-ß transcriptional regulation is tissue-specific in early atherosclerosis. The computational methods included 5 steps: (i) from microarray data of human atherosclerotic carotid tissue, t...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2014-05, Vol.103 (5-6), p.357-370
Main Authors: Dhaouadi, Nedra, Li, Jacques-Yuan, Feugier, Patrick, Gustin, Marie-Paule, Dab, Houcine, Kacem, Kamel, Bricca, Giampiero, Cerutti, Catherine
Format: Article
Language:English
Subjects:
arteries
Atherosclerosis
Binding Sites
Carotid Arteries - pathology
Carotid Artery Diseases - metabolism
Cells, Cultured
Computer Simulation
Early Growth Response Protein 1 - physiology
Gene co-expression
Gene Expression
Gene Expression Regulation
Humans
Kruppel-Like Factor 6
Kruppel-Like Transcription Factors - physiology
metastasis
Microarray
microarray technology
Models, Genetic
Multigene Family
Muscle, Smooth, Vascular - pathology
Myocytes, Smooth Muscle - metabolism
neoplasms
Organ Specificity
Promoter Regions, Genetic
Proto-Oncogene Proteins - physiology
Sp1 Transcription Factor - physiology
transactivators
transcription (genetics)
Transcriptome
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-beta 1
Vascular smooth muscle cells
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