Complementary Sequence-Mediated Exon Circularization

Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences....

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Bibliographic Details
Published in:Cell 2014-09, Vol.159 (1), p.134-147
Main Authors: Zhang, Xiao-Ou, Wang, Hai-Bin, Zhang, Yang, Lu, Xuhua, Chen, Ling-Ling, Yang, Li
Format: Article
Language:English
Subjects:
Alternative Splicing
Alu Elements
Animals
Base Sequence
biogenesis
Embryonic Stem Cells - metabolism
Evolution, Molecular
Exons
Genome, Human
Humans
Introns
loci
Mammals - genetics
messenger RNA
Molecular Sequence Data
Nucleic Acid Conformation
Sequence Alignment
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