The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increas...

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Bibliographic Details
Published in:Cell 2015-04, Vol.161 (3), p.610-621
Main Authors: Rungta, Ravi L., Choi, Hyun B., Tyson, John R., Malik, Aqsa, Dissing-Olesen, Lasse, Lin, Paulo J.C., Cain, Stuart M., Cullis, Pieter R., Snutch, Terrance P., MacVicar, Brian A.
Format: Article
Language:English
Subjects:
Animals
brain
Brain Edema - metabolism
Brain Edema - pathology
Cell Death
Cells, Cultured
Chloride-Bicarbonate Antiporters - chemistry
Chloride-Bicarbonate Antiporters - metabolism
cytotoxicity
death
edema
fluorescence
Humans
image analysis
In Vitro Techniques
infarction
Membrane Transport Proteins - chemistry
Membrane Transport Proteins - metabolism
Mice
mortality
neurons
Neurons - metabolism
Neurons - pathology
Rats
screening
sodium
Sodium - metabolism
sodium chloride
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