IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly metabolic fitness, remain elusive. We discover that IL-7 induces expression of the glycerol channel aquaporin 9 (AQP...

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Bibliographic Details
Published in:Cell 2015-05, Vol.161 (4), p.750-761
Main Authors: Cui, Guoliang, Staron, Matthew M., Gray, Simon M., Ho, Ping-Chih, Amezquita, Robert A., Wu, Jingxia, Kaech, Susan M.
Format: Article
Language:English
Subjects:
Animals
aquaporins
Aquaporins - metabolism
Arenaviridae Infections - immunology
CD8-positive T-lymphocytes
CD8-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cell Survival
cell viability
esterification
fatty acids
glycerol
Glycerol - metabolism
Humans
immunity
Immunologic Memory
interleukin-7
Interleukin-7 - metabolism
longevity
Lymphocytic choriomeningitis virus - physiology
metabolism
Mice
Signal Transduction
triacylglycerols
Triglycerides - metabolism
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