Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Activated T cells engage aerobic glycolysis and anabolic metabolism for growth, proliferation, and effector functions. We propose that a glucose-poor tumor microenvironment limits aerobic glycolysis in tumor-infiltrating T cells, which suppresses tumoricidal effector functions. We discovered a new r...

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Bibliographic Details
Published in:	Cell 2015-09, Vol.162 (6), p.1217-1228
Main Authors:	Ho, Ping-Chih, Bihuniak, Jessica Dauz, Macintyre, Andrew N., Staron, Matthew, Liu, Xiaojing, Amezquita, Robert, Tsui, Yao-Chen, Cui, Guoliang, Micevic, Goran, Perales, Jose C., Kleinstein, Steven H., Abel, E. Dale, Insogna, Karl L., Feske, Stefan, Locasale, Jason W., Bosenberg, Marcus W., Rathmell, Jeffrey C., Kaech, Susan M.
Format:	Article
Language:	English
Subjects:	Animals Ca2-transporting ATPase Calcium - metabolism CD4-Positive T-Lymphocytes - immunology CD8-positive T-lymphocytes Endoplasmic Reticulum - metabolism Glycolysis Hexokinase - metabolism Immunotherapy Lymphocytes, Tumor-Infiltrating - immunology Melanoma - immunology Melanoma - therapy metabolites Mice Monitoring, Immunologic NFATC Transcription Factors - metabolism Phosphoenolpyruvate - metabolism Receptors, Antigen, T-Cell - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Signal Transduction Transforming Growth Factor beta - immunology Tumor Microenvironment
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