Simultaneous determination of imigliptin and its three metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry

•Imigliptin is a novel anti-diabetic drug.•Imigliptin and its three metabolites concentration were firstly determined in plasma and urine by LC–MS/MS method.•The method was proved to be a robust, accurate and specified method. A specific and sensitive method was firstly developed using high performa...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-10, Vol.1002, p.300-312
Main Authors: Liu, Yang, Liu, Dongyang, Liu, Hongzhong, Song, Hanlin, Song, Lin, Yao, Xueting, Wu, Frank, Shu, Chutian, Ma, Xifeng, Zhou, Huimin, Jiang, Ji, Hu, Pei
Format: Article
Language:English
Subjects:
acetonitrile
ammonium acetate
Chromatography, High Pressure Liquid - methods
high performance liquid chromatography
Human plasma and urine
Humans
Hypoglycemic Agents - blood
Hypoglycemic Agents - pharmacokinetics
Hypoglycemic Agents - urine
Imidazoles - blood
Imidazoles - pharmacokinetics
Imidazoles - urine
Imigliptin and metabolites
ionization
LC–MS/MS
metabolites
monitoring
pharmacokinetics
Pyridines - blood
Pyridines - pharmacokinetics
Pyridines - urine
Reproducibility of Results
solid phase extraction
tandem mass spectrometry
Tandem Mass Spectrometry - methods
urine
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