Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City

Children's air pollution exposures are associated with systemic and brain inflammation and the early hallmarks of Alzheimer's disease (AD). The Apolipoprotein E (APOE) 4 allele is the most prevalent genetic risk for AD, with higher risk for women. We assessed whether gender, BMI, APOE and...

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Bibliographic Details
Published in:	Environmental research 2016-10, Vol.150, p.411-422
Main Authors:	Calderón-Garcidueñas, Lilian, Jewells, Valerie, Galaz-Montoya, Carolina, van Zundert, Brigitte, Pérez-Calatayud, Angel, Ascencio-Ferrel, Eric, Valencia-Salazar, Gildardo, Sandoval-Cano, Marcela, Carlos, Esperanza, Solorio, Edelmira, Acuña-Ayala, Hilda, Torres-Jardón, Ricardo, D’Angiulli, Amedeo
Format:	Article
Language:	English
Subjects:	Adolescent Air Pollutants - analysis Air pollution alleles Alzheimer Alzheimer disease Apoe apolipoprotein E Apolipoprotein E4 - genetics Blood Glucose - analysis Body Mass Index Child Children chronic exposure Cities Cognition Cognition deficits encephalitis Environmental Exposure - adverse effects Environmental Exposure - analysis fasting Female Females Fine particulate matter Gender glucose heterozygosity Humans insulin leptin Male memory Mexico Mexico city Neuroprevention Ozone Ozone - analysis Particulate Matter - analysis particulates risk Wechsler Scales WISC(R) women
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