Preparation of polysaccharide derivates chitosan-graft-poly(ɛ-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery

Biodegradable graft copolymer, chitosan-graft-poly(ɛ-caprolactone) (CS-g-PCL) was synthesized via ring opening polymerization and characterized by (1)H NMR and FTIR spectroscopy. Then graft copolymers were self-assembled into micelles as drug delivery system. To evaluate drug-polymer compatibility,...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-04, Vol.116, p.745-750
Main Authors: Gu, Chunhua, Le, Vanminh, Lang, Meidong, Liu, Jianwen
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
apoptosis
aqueous solutions
biocompatibility
biodegradability
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cellular
chitosan
Chitosan - analogs & derivatives
Chitosan - chemical synthesis
Chitosan - chemistry
colloids
composite polymers
Computing time
cytotoxicity
Dose-Response Relationship, Drug
Drug Delivery Systems
Drug Screening Assays, Antitumor
Drugs
fluorouracil
Fluorouracil - chemistry
Fluorouracil - pharmacology
Fourier transform infrared spectroscopy
Graft copolymers
Humans
hydrophobicity
Interaction parameters
kinetics
Mathematical models
MCF-7 Cells
Micelles
Molecular Structure
nuclear magnetic resonance spectroscopy
particle size
Polyesters - chemical synthesis
Polyesters - chemistry
polymerization
Polysaccharides - chemical synthesis
Polysaccharides - chemistry
Structure-Activity Relationship
Surface-Active Agents - chemical synthesis
Surface-Active Agents - chemistry
transmission electron microscopy
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