Preparation of polysaccharide derivates chitosan-graft-poly(ɛ-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery

Biodegradable graft copolymer, chitosan-graft-poly(ɛ-caprolactone) (CS-g-PCL) was synthesized via ring opening polymerization and characterized by (1)H NMR and FTIR spectroscopy. Then graft copolymers were self-assembled into micelles as drug delivery system. To evaluate drug-polymer compatibility,...

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Bibliographic Details
Published in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-04, Vol.116, p.745-750
Main Authors:	Gu, Chunhua, Le, Vanminh, Lang, Meidong, Liu, Jianwen
Format:	Article
Language:	English
Subjects:	anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology apoptosis aqueous solutions biocompatibility biodegradability Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cellular chitosan Chitosan - analogs & derivatives Chitosan - chemical synthesis Chitosan - chemistry colloids composite polymers Computing time cytotoxicity Dose-Response Relationship, Drug Drug Delivery Systems Drug Screening Assays, Antitumor Drugs fluorouracil Fluorouracil - chemistry Fluorouracil - pharmacology Fourier transform infrared spectroscopy Graft copolymers Humans hydrophobicity Interaction parameters kinetics Mathematical models MCF-7 Cells Micelles Molecular Structure nuclear magnetic resonance spectroscopy particle size Polyesters - chemical synthesis Polyesters - chemistry polymerization Polysaccharides - chemical synthesis Polysaccharides - chemistry Structure-Activity Relationship Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry transmission electron microscopy
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