Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Lipid nanoparticles (LNP) can provide a clinically effective method for delivering small interfering RNA (siRNA) to silence pathological genes in hepatocytes. The gene silencing potency of these LNP-siRNA systems has been shown to depend on a variety of factors including association with serum facto...

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Bibliographic Details
Published in:Journal of controlled release 2016-08, Vol.235, p.236-244
Main Authors: Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Sung, Molly M.H., Tam, Ying K., Cullis, Pieter R.
Format: Article
Language:English
Subjects:
Administration, Intravenous
Animals
blood serum
coatings
dissociation
Drug delivery
Factor VII - genetics
Factor VII - metabolism
Female
Gene Silencing
genes
hepatocytes
intravenous injection
Lipid exchange
Lipid nanoparticles
lipids
Lipids - administration & dosage
Lipids - pharmacokinetics
Liposomes
Liver - metabolism
Mice
Mice, Inbred C57BL
Nanomedicine
nanoparticles
Nanoparticles - administration & dosage
Particle Size
pharmacokinetics
polyethylene glycol
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - pharmacokinetics
siRNA
small interfering RNA
Tissue Distribution
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