Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

Immunological tolerance to self requires naturally occurring regulatory T (Treg) cells. Yet how they stably control autoimmune T cells remains obscure. Here, we show that Treg cells can render self-reactive human CD8+ T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen r...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2014-12, Vol.346 (6216), p.1536-1540
Main Authors: Maeda, Yuka, Nishikawa, Hiroyoshi, Sugiyama, Daisuke, Ha, Danbee, Hamaguchi, Masahide, Saito, Takuro, Nishioka, Megumi, Wing, James B., Adeegbe, Dennis, Katayama, Ichiro, Sakaguchi, Shimon
Format: Article
Language:English
Subjects:
Antigen presenting cells
Antigen-Presenting Cells - immunology
Antigens
Autoimmune diseases
Autoimmune Diseases - immunology
CD8-positive T-lymphocytes
CD8-Positive T-Lymphocytes - immunology
Clonal Anergy
CTLA-4 Antigen
Culture
Cytokines
cytotoxicity
Gene expression
Genotype & phenotype
Government regulations
Humans
Immune system
Immune systems
Immunity
Lymphocyte Activation
Lymphocytes
Messenger RNA
Molecules
phenotype
Phenotypes
Receptors, Antigen, T-Cell - immunology
Self Tolerance
Silence
Skin diseases
T lymphocytes
T-Lymphocytes, Regulatory - immunology
Tolerances
Vitiligo
Vitiligo - immunology
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