Transcriptional Addiction in Cancer

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alteratio...

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Bibliographic Details
Published in:Cell 2017-02, Vol.168 (4), p.629-643
Main Authors: Bradner, James E., Hnisz, Denes, Young, Richard A.
Format: Article
Language:English
Subjects:
Animals
DNA Methylation
Epigenesis, Genetic
gene expression
Gene Expression Regulation, Neoplastic
Homeostasis
Humans
neoplasm cells
neoplasms
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
regulator genes
transcription (genetics)
Transcription Factors - metabolism
Transcription, Genetic
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