Heterogeneous Differentiation Patterns of Individual CD8⁺ T Cells

Upon infection, antigen-specific CD8⁺ T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a uniform behavior of individual cells. We tracked the progeny of individual mouse CD8⁺ T cells by in vivo lineage tracing and demonstrated that,...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2013-05, Vol.340 (6132), p.635-639
Main Authors: Gerlach, Carmen, Rohr, Jan C., Perié, Leïla, van Rooij, Nienke, van Heijst, Jeroen W. J., Velds, Arno, Urbanus, Jos, Naik, Shalin H., Jacobs, Heinz, Beltman, Joost B., de Boer, Rob J., Schumacher, Ton N. M.
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
Antigens
Asymmetric Cell Division
Bacteria
Bacterial diseases
bacterial infections
Bar codes
CD8-positive T-lymphocytes
CD8-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation
Cell Lineage
Cell Proliferation
Cells
clones
Differentiation
Dynamics
Effectors
Family size
Fate
Feedback (Response)
Heterogeneity
Immune response
Immunity
Immunity, Cellular
Immunologic Memory
Immunology
Immunophenotyping
Individualized Instruction
Infections
Life Sciences
Listeria monocytogenes
Listeriosis - immunology
Lymphocytes
Mapping
Memory
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Immunological
Online
Pathogens
Pools
Receptors, Antigen, T-Cell - immunology
Research fellowships
Single-Cell Analysis
Stochastic Processes
T lymphocytes
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
Trucks
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