Examination of the superoxide/hydrogen peroxide forming and quenching potential of mouse liver mitochondria

Pyruvate dehydrogenase (PDHC) and α-ketoglutarate dehydrogenase complex (KGDHC) are important sources of reactive oxygen species (ROS). In addition, it has been found that mitochondria can also serve as sinks for cellular hydrogen peroxide (H2O2). However, the ROS forming and quenching capacity of l...

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Bibliographic Details
Published in:Biochimica et biophysica acta. General subjects 2017-08, Vol.1861 (8), p.1960-1969
Main Authors: Slade, Liam, Chalker, Julia, Kuksal, Nidhi, Young, Adrian, Gardiner, Danielle, Mailloux, Ryan J.
Format: Article
Language:English
Subjects:
alpha-ketoglutaric acid
Animals
Antioxidant defense
Caprylates - pharmacology
catalase
Catalase - physiology
electron transfer
Electron Transport Complex III - physiology
glutathione
Glutathione - metabolism
Hydrogen peroxide
Hydrogen Peroxide - metabolism
Ketoglutarate Dehydrogenase Complex - physiology
Krebs cycle
Liver
Male
Methacrylates - pharmacology
Mice
Mice, Inbred C57BL
Mitochondria
Mitochondria, Liver - metabolism
NAD (coenzyme)
oxidation
peroxiredoxin
Peroxiredoxins - physiology
pyruvate dehydrogenase (lipoamide)
pyruvic acid
Reactive Oxygen Species - metabolism
rotenone
Sulfides - pharmacology
Superoxide
Superoxides - metabolism
Thiazoles - pharmacology
thioredoxins
titration
triazoles
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