Protective mechanisms of hypaconitine and glycyrrhetinic acid compatibility in oxygen and glucose deprivation injury

This study investigated the protective effect of the compatibility of hypaconitine (HA) and glycyrrhetinic acid (GA) on H9c2 cells under oxygen and glucose deprivation (OGD)-induced injury, and the possible mechanisms. We found that HA+GA significantly improved pathology and morphology of the nucleu...

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Bibliographic Details
Published in:	Journal of Zhejiang University. B. Science 2017-07, Vol.18 (7), p.586-596
Main Authors:	Wang, Li-qin, He, Yu, Wan, Hao-fang, Zhou, Hui-fen, Yang, Jie-hong, Wan, Hai-tong
Format:	Article
Language:	English
Subjects:	1-Phosphatidylinositol 3-kinase Aconitine - analogs & derivatives Aconitine - pharmacology Aconitum AKT protein Animals Annexin V Anti-Inflammatory Agents - pharmacology Apoptosis Aspartate transaminase BAX protein Bcl-2 protein Biomedical and Life Sciences Biomedicine Caspase Caspase-9 Cell Survival Compatibility Creatine Creatine kinase Creatine Kinase, MB Form - metabolism Deprivation Electron microscopy Enzyme-Linked Immunosorbent Assay Fluorescein Fluorescein isothiocyanate Glucose Glucose - metabolism Glycyrrhetinic Acid - pharmacology Heart Diseases - physiopathology Injuries Iodides isozymes Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Microscopy, Electron, Transmission Necrosis Nuclei Nuclei (cytology) Oxygen Oxygen - metabolism phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism propidium Propidium iodide protective effect protein synthesis Rats Signal Transduction Signaling sorbents Staining Transaminase Transmission electron microscopy Ultrastructure
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