Folding Mechanism of Proteins Im7 and Im9: Insight from All-Atom Simulations in Implicit and Explicit Solvent

Im7 and Im9 are evolutionary related proteins with almost identical native structures. In spite of their structural similarity, experiments show that Im7 folds through a long-lived on-pathway intermediate, while Im9 folds according to two-state kinetics. In this work, we use a recently developed enh...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2016-09, Vol.120 (35), p.9297-9307
Main Authors: Wang, F, Cazzolli, G, Wintrode, P, Faccioli, P
Format: Article
Language:English
Subjects:
Carrier Proteins - chemistry
Escherichia coli - chemistry
Escherichia coli Proteins - chemistry
Evolutionary
Folding
Kinetics
Molecular dynamics
Molecular Dynamics Simulation
Protein Folding
Proteins
Similarity
Simulation
Solvents
Solvents - chemistry
Trajectories
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