Electrospun Blends of Gelatin and Gelatin–Dendrimer Conjugates As a Wound-Dressing and Drug-Delivery Platform

In this work, we report a new nanofiber construct based on electrospun blends of gelatin and gelatin–dendrimer conjugates. Highly branched star-shaped polyamidoamine (PAMAM) dendrimer G3.5 was covalently conjugated to gelatin via EDC/NHS chemistry. Blends of gelatin and gelatin–dendrimer conjugates...

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Bibliographic Details
Published in:Biomacromolecules 2013-11, Vol.14 (11), p.4038-4045
Main Authors: Dongargaonkar, Alpana A, Bowlin, Gary L, Yang, Hu
Format: Article
Language:English
Subjects:
acetates
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antimicrobial properties
Applied sciences
aqueous solutions
Bandages
Biocompatible Materials - chemistry
Biological and medical sciences
chemical bonding
Dendrimers - chemistry
diameter
Drug Delivery Systems
drugs
Exact sciences and technology
Forms of application and semi-finished materials
gelatin
Gelatin - chemistry
General pharmacology
Kinetics
mechanical properties
Medical sciences
Microbial Sensitivity Tests
Miscellaneous
Molecular Structure
nanofibers
pathogens
permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polyethylene glycol
Polymer industry, paints, wood
Porosity
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
silver
Silver - analysis
Silver - chemistry
Silver - pharmacology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
swelling (materials)
Technology of polymers
Technology. Biomaterials. Equipments
Wound Healing - drug effects
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