Porous stable poly(lactic acid)/ethyl cellulose/hydroxyapatite composite scaffolds prepared by a combined method for bone regeneration

• Published in: Carbohydrate polymers 2018-01, Vol.180, p.104-111
• Main Authors: Mao, Daoyong, Li, Qing, Bai, Ningning, Dong, Hongzhou, Li, Daikun
• Format: Article
• Language: English
• Subjects: ambient temperature; biomimetics; bone substitutes; Bone tissue engineering; bones; cellulose; contact angle; Ethyl cellulose; Hydroxyapatite; leaching; Poly(lactic acid); polylactic acid; porosity; Scaffold; solvents; strength (mechanics); tissue engineering; weight loss
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2017.10.031

•The composites consisted of poly(lactic acid), ethyl cellulose, and hydroxyapatite.•The scaffolds were fabricated via a combined method.•The scaffolds showed compact porous architecture for load-bearing bone substitute.•The scaffolds held initial dimensions during degradation. A major challenge in bone tissue engineering is the development of biomimetic scaffolds which should simultaneously meet mechanical strength and pore structure requirements. Herein, we combined technologies of high concentration solvent casting, particulate leaching, and room temperature compression molding to prepare a novel poly(lactic acid)/ethyl cellulose/hydroxyapatite (PLA/EC/HA) scaffold. The functional, structural and mechanical properties of the obtained porous scaffolds were characterized. The results indicated that the PLA/EC/HA scaffolds at the 20wt% HA loading level showed optimal mechanical properties and desired porous structure. Its porosity, contact angle, compressive yield strength and weight loss after 56days were 84.28±7.04%, 45.13±2.40°, 1.57±0.09MPa and 4.77±0.32%, respectively, which could satisfy the physiological demands to guide bone regeneration. Thus, the developed scaffolds have potential to be used as a bone substitute material for bone tissue engineering application.