Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK

Diisodecyl phthalate (DIDP) is considered to be one of the less toxic phthalates. However epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The effect of DIDP exposure on allergic asthma and the underlying mechanism have not been fully elucidated. Here, mice were...

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Bibliographic Details
Published in:Food and chemical toxicology 2018-04, Vol.114, p.78-87
Main Authors: Qin, Wei, Deng, Ting, Cui, Haiyan, Zhang, Qian, Liu, Xudong, Yang, Xu, Chen, Mingqing
Format: Article
Language:English
Subjects:
Asthma
Diisodecyl phthalate (DIDP)
epidemiological studies
immunity
immunoglobulin E
interleukin-17
interleukin-1beta
mice
mitogen-activated protein kinase
Oxidative stress
p38 MAPK
phthalates
Th2/Th17
toxicity
toxicology
vitamin E
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