Effectiveness of a multicomponent self-management intervention for adults with epilepsy (ZMILE study): A randomized controlled trial

The objective of the ZMILE study was to compare the effectiveness of a multicomponent self-management intervention (MCI) with care as usual (CAU) in adult patients with epilepsy (PWE) over a six-month period. Participants (PWE & relative) were randomized into intervention or CAU groups. Self-rep...

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Bibliographic Details
Published in:Epilepsy & behavior 2018-03, Vol.80, p.259-265
Main Authors: Leenen, Loes A.M., Wijnen, Ben F.M., Kessels, Alfons G.H., Chan, HoiYau, de Kinderen, Reina J.A., Evers, Silvia M.A.A., van Heugten, Caroline M., Majoie, Marian H.J.M.
Format: Article
Language:English
Subjects:
Adaptation, Psychological
Adult
Aged
Anticonvulsants - therapeutic use
Emotions
Epilepsy
Epilepsy - psychology
Epilepsy - therapy
Female
Goal-setting
Group intervention
Humans
Male
Medication Adherence
Middle Aged
Multicomponent intervention
Outcome Assessment (Health Care)
Patient Education as Topic - methods
PWE & relative
Quality of Life - psychology
Seizures - drug therapy
Self Efficacy
Self-management
Self-Management - methods
Surveys and Questionnaires
Young Adult
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Summary:The objective of the ZMILE study was to compare the effectiveness of a multicomponent self-management intervention (MCI) with care as usual (CAU) in adult patients with epilepsy (PWE) over a six-month period. Participants (PWE & relative) were randomized into intervention or CAU groups. Self-report questionnaires were used to measure disease-specific self-efficacy as the primary outcome measure and general self-efficacy, adherence, seizure severity, emotional functioning, quality of life, proactive coping, and side-effects of antiepileptic drugs (AED) as secondary outcome measures. Instruments used at baseline and during a six-month follow-up period were the following: disease-specific self-efficacy (Epilepsy Self-Efficacy Scale [ESES], General Self-Efficacy Scale [GSES]); adherence (Medication Adherence Scale [MARS] and Medication Event Monitoring System [MEMS]); seizure severity (National Hospital Seizure Severity Scale [NHS3]); emotional well-being (Hospital Anxiety and Depression Scale [HADS]); quality of life (Quality of Life in Epilepsy [QOLIE-31P]); proactive coping (Utrecht Proactive Coping Competence [UPCC]); and side-effects of antiepileptic drugs [SIDAED]. Multilevel analyses were performed, and baseline differences were corrected by inclusion of covariates in the analyses. In total, 102 PWE were included in the study, 52 of whom were in the intervention group. On the SIDAED and on three of the quality of life subscales QOLIE-31P, a significant difference was found (p
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2018.01.019