Proliferative Lesions of the Endometrium of 50 Four-Toed Hedgehogs (Atelerix albiventris)

Uteri from 50 four-toed hedgehogs (Atelerix albiventris) with clinical signs of uterine disease were histopathologically examined. Sixteen animals (32%) were diagnosed with endometrial hyperplasia, 7 animals (14%) were diagnosed with endometrial polyp, and 27 animals (54%) were diagnosed with endome...

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Bibliographic Details
Published in:Veterinary pathology 2018-07, Vol.55 (4), p.562-571
Main Authors: Chambers, James K., Shiga, Takanori, Takimoto, Haruka, Dohata, Atsushi, Miwa, Yasutsugu, Nakayama, Hiroyuki, Uchida, Kazuyuki
Format: Article
Language:English
Subjects:
Animals
Endometrial Neoplasms - pathology
Endometrial Neoplasms - veterinary
Endometrium - pathology
Female
Hedgehogs
Immunohistochemistry - veterinary
Phenotype
Polyps - pathology
Polyps - veterinary
Receptors, Progesterone - metabolism
Sarcoma, Endometrial Stromal - pathology
Sarcoma, Endometrial Stromal - veterinary
Uterine Neoplasms - pathology
Uterine Neoplasms - veterinary
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Summary:Uteri from 50 four-toed hedgehogs (Atelerix albiventris) with clinical signs of uterine disease were histopathologically examined. Sixteen animals (32%) were diagnosed with endometrial hyperplasia, 7 animals (14%) were diagnosed with endometrial polyp, and 27 animals (54%) were diagnosed with endometrial neoplasia. The mean ages of the animals with endometrial hyperplasia, polyp, and neoplasia were 28.7 months, 29.4 months, and 25.2 months, respectively. The neoplasms were classified into 7 endometrial mixed tumors, 12 endometrial stromal nodules, and 8 endometrial stromal sarcomas. However, the endometrial stromal nodules and endometrial stromal sarcomas often developed within or were contiguous with an endometrial polyp or mixed tumor. Interestingly, the stromal tumors and the stromal components of the endometrial polyp and mixed tumor displayed extraendometrial differentiation (eg, into adipocytes, granular cells, smooth muscle cells, and osteoid tissue). The endometrial stromal sarcomas exhibited severe cellular atypia and invaded subendometrial tissue. Immunohistochemical examinations demonstrated that the stromal cells of the hyperplastic lesions as well as the neoplastic lesions were positive for CD10, the progesterone receptor, and Wilms tumor 1. The four-toed hedgehog develops unique uterine neoplasms that are mainly composed of endometrial stromal cells and probably arise from endometrial polyps and/or mixed tumors.
ISSN:0300-9858
1544-2217
DOI:10.1177/0300985818758467