Inflammation as a Possible Link Between Dyslipidemia and Alzheimer’s Disease

•The increasing incidence of Alzheimer’s disease may be connected to population habits.•Inflammation and dyslipidemia contribute to the development of Alzheimer’s disease.•Dyslipidemia may induce inflammation, which could contribute to Alzheimer’s disease. Alzheimer's disease (AD) is the leadin...

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Bibliographic Details
Published in:Neuroscience 2018-04, Vol.376, p.127-141
Main Authors: Oliveira, Bruno Cabral de Lima, Bellozi, Paula Maria Quaglio, Reis, Helton José, de Oliveira, Antônio Carlos Pinheiro
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer’s disease
Animals
cholesterol
dyslipidemia
Dyslipidemias - metabolism
Humans
inflammasome
inflammation
Inflammation - metabolism
memory
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Summary:•The increasing incidence of Alzheimer’s disease may be connected to population habits.•Inflammation and dyslipidemia contribute to the development of Alzheimer’s disease.•Dyslipidemia may induce inflammation, which could contribute to Alzheimer’s disease. Alzheimer's disease (AD) is the leading cause of dementia worldwide. This pathological condition is characterized not only by Aβ and tau accumulation in the central nervous system (CNS), but also by inflammation, processes that can lead to neurodegeneration. Besides that, other factors may contribute to the development of AD, such as dyslipidemias. Changes in lipid levels can either influence the activity of enzymes related to the protein deposition that occurs in this pathological condition, or enhance the peripheral and CNS immune responses. Furthermore, cholesterol-associated genes are frequently associated with AD. Here, we extensively reviewed the literature and, based on the existing evidences, we suggest inflammation as an important link between dyslipidemias and AD.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2018.02.012