Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening

The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the g...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2018-02, Vol.16 (2), p.125-130
Main Authors: Ali, Babar, Ali, Mohammad, Amin, Saima, Mir, Showkat R.
Format: Article
Language:English
Subjects:
Amoxicillin
Bioavailability
Everted rat sac
Homolabdane
Nigella sativa
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Summary:The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(18)30038-4