The association of IgA deficiency on infection rate, self‐perceived health, and levels of C‐reactive protein in healthy blood donors

The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self‐reported mental and physical health and the risk of infection in IgA‐deficient blood donors compared to healthy control blood donors. Infectious event...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2018-03, Vol.126 (3), p.248-256
Main Authors: Hauge, Sabina Chaudhary, Jensen, Charlotte Kæstel, Nielsen, Leif Kofoed, Pedersen, Ole B., Sørensen, Erik, Thørner, Lise Wegner, Hjalgrim, Henrik, Erikstrup, Christian, Nielsen, Kaspar René, Kaspersen, Kathrine Agergård, Didriksen, Maria, Dziegiel, Morten, Ullum, Henrik
Format: Article
Language:English
Subjects:
Adult
Antiinfectives and antibacterials
Blood
Blood & organ donations
Blood Donors
C-Reactive Protein - metabolism
C‐reactive protein
Denmark - epidemiology
Diagnostic Self Evaluation
Female
Genetic Predisposition to Disease
Health care
Health risks
Humans
IgA deficiency
IgA Deficiency - genetics
IgA Deficiency - immunology
Immunoglobulin A
Immunoglobulin A - genetics
Immunoglobulin A - immunology
infection
Infection - epidemiology
Infection - immunology
Infections
Male
Medicine
Mental health
Middle Aged
Nosocomial infections
Public health
quality of life
Risk
Surveys and Questionnaires
Young Adult
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Summary:The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self‐reported mental and physical health and the risk of infection in IgA‐deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA‐deficient blood donors and 1770 control blood donors. A subset of the IgA‐deficient donors were further characterized by self‐reported health (Short Form‐12, n = 28) and circulating C‐reactive protein (CRP) (n = 10). IgA‐deficient individuals had lower self‐reported mental health (p = 0.01) and higher CRP (p 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12807