Are the MDS‐UPDRS–Based Composite Scores Clinically Applicable?

Background: The International Parkinson and Movement Disorder Society–sponsored UPDRS (MDS‐UPDRS) is a powerful clinical outcome measure. Objectives: To evaluate the feasibility of various MDS‐UPDRS‐based composite scores and determine their minimal clinically important difference threshold values....

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Bibliographic Details
Published in:Movement disorders 2018-05, Vol.33 (5), p.835-839
Main Authors: Makkos, Attila, Kovács, Márton, Aschermann, Zsuzsanna, Harmat, Márk, Janszky, József, Karádi, Kázmér, Kovács, Norbert
Format: Article
Language:English
Subjects:
Cognition Disorders - etiology
Disability Evaluation
Female
Humans
International Cooperation
Longitudinal Studies
Male
minimal but clinically relevant differences
minimal clinically important changes
Minimal Clinically Important Difference
Movement disorders
Movement Disorders - complications
Movement Disorders - diagnosis
Parkinson's disease
patient‐reported outcomes
receiver operating characteristic curve
Regression (Psychology)
Severity of Illness Index
United Kingdom
UPDRS
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Summary:Background: The International Parkinson and Movement Disorder Society–sponsored UPDRS (MDS‐UPDRS) is a powerful clinical outcome measure. Objectives: To evaluate the feasibility of various MDS‐UPDRS‐based composite scores and determine their minimal clinically important difference threshold values. Methods: Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. Results: Based on the ordinal regression modeling, the MDS‐UPDRS II+III, MDS‐UPDRS I+II+III, and the total score of MDS‐UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS‐UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS‐UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS‐UPDRS were 7.1 points for improvement and 6.3 points for worsening. Conclusions: Our findings support the application of various MDS‐UPDRS–based composite scores. © 2018 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.27303