One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

A sequential one-pot approach towards N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This pr...

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Published in:Organic & biomolecular chemistry 2018-03, Vol.16 (12), p.2143-2149
Main Authors: Demjén, András, Angyal, Anikó, Wölfling, János, Puskás, László G, Kanizsai, Iván
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Language:English
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Amines
Guanidines
Substrates
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cited_by cdi_FETCH-LOGICAL-c315t-57302dee3f8f7e1e2be4d10c22b00127f6fd2786bb422289cdf6d022dd4ef8cc3
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creator Demjén, András
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description A sequential one-pot approach towards N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.
doi_str_mv 10.1039/c7ob03109b
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source Royal Society of Chemistry
subjects Amines
Guanidines
Substrates
title One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines
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