Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain

As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of...

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Published in:Phytomedicine (Stuttgart) 2018-03, Vol.41, p.1-6
Main Authors: Shevelev, Oleg B., Seryapina, Alisa A., Zavjalov, Evgenii L., Gerlinskaya, Lyudmila A., Goryachkovskaya, Tatiana N., Slynko, Nikolay M., Kuibida, Leonid V., Peltek, Sergey E., Markel, Arcady L., Moshkin, Mikhail P.
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Brain metabolites
Carotid Arteries - drug effects
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Cerebrovascular Circulation - drug effects
Dietary Supplements
Hypertension
Hypertension - diet therapy
Hypertension - drug therapy
Losartan - pharmacology
Male
Nootropic Agents - pharmacology
Phytotherapy - methods
Rats, Inbred Strains
Reishi
Reishi - chemistry
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Summary:As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats. After seven weeks, Reishi therapy reduced blood pressure in experimental animals at a level comparable to that of losartan. Unlike losartan, intragastric Reishi introduction significantly increases cerebral blood flow and affects cerebral cortex metabolic patterns, shifting the balance of inhibitory and excitatory neurotransmitters toward excitation. Changes in cerebral blood flow and ratios of neurometabolites suggests Reishi has a potential nootropic effect. [Display omitted]
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2018.01.013