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Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria
Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resis...
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| Published in: | Applied microbiology and biotechnology 2018-05, Vol.102 (10), p.4243-4253 |
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| Main Authors: | , |
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| cites | cdi_FETCH-LOGICAL-c576t-5b8943dff4eeb76404d326015d07207e2bf01985d789fe3d28a59bb2f15522053 |
| container_end_page | 4253 |
| container_issue | 10 |
| container_start_page | 4243 |
| container_title | Applied microbiology and biotechnology |
| container_volume | 102 |
| creator | Zheng, Sen Sonomoto, Kenji |
| description | Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resistant bacteria such as methicillin-resistant
Staphylococcus aureus
and vancomycin-resistant
Enterococcus
. As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation. |
| doi_str_mv | 10.1007/s00253-018-8917-5 |
| format | article |
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Staphylococcus aureus
and vancomycin-resistant
Enterococcus
. As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-018-8917-5</identifier><identifier>PMID: 29560521</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antibiotic resistance ; Antibiotics ; Antimicrobial peptides ; Bacteria ; Bacteriocins ; Bacteriocins - genetics ; Bacteriocins - metabolism ; Bacteriocins - pharmacology ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Chemistry, Pharmaceutical - trends ; Drug resistance ; Gram-positive bacteria ; Gram-Positive Bacteria - physiology ; Health aspects ; Life Sciences ; Membrane proteins ; Membrane Transport Proteins - metabolism ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Genetics and Genomics ; Microbiology ; Mini-Review ; Peptides ; Proteins ; Secretion ; Staphylococcus infections ; Vancomycin</subject><ispartof>Applied microbiology and biotechnology, 2018-05, Vol.102 (10), p.4243-4253</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-5b8943dff4eeb76404d326015d07207e2bf01985d789fe3d28a59bb2f15522053</citedby><cites>FETCH-LOGICAL-c576t-5b8943dff4eeb76404d326015d07207e2bf01985d789fe3d28a59bb2f15522053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2015888687/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2015888687?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,11688,27924,27925,36060,36061,44363,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29560521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Sen</creatorcontrib><creatorcontrib>Sonomoto, Kenji</creatorcontrib><title>Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resistant bacteria such as methicillin-resistant
Staphylococcus aureus
and vancomycin-resistant
Enterococcus
. As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial peptides</subject><subject>Bacteria</subject><subject>Bacteriocins</subject><subject>Bacteriocins - genetics</subject><subject>Bacteriocins - metabolism</subject><subject>Bacteriocins - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Chemistry, Pharmaceutical - trends</subject><subject>Drug resistance</subject><subject>Gram-positive bacteria</subject><subject>Gram-Positive Bacteria - physiology</subject><subject>Health aspects</subject><subject>Life Sciences</subject><subject>Membrane proteins</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mini-Review</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Secretion</subject><subject>Staphylococcus infections</subject><subject>Vancomycin</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp1kUtv1TAQhS0EopfCD2CDIrGBhcvYiV_LqhSoVAmJx4KV5STji6ubONgJtP8eR7elugjkheWZb47m-BDynMEJA1BvMgAXNQWmqTZMUfGAbFhTcwqSNQ_JBpgSVAmjj8iTnK8AGNdSPiZH3AgJgrMN-fY2_MSUgw_YV3NyY55imkulcmNfTW7-_svd5MrHVLWuK40QuzBWGbuEc4hjVR7b5AY6xRzmonWHuafkkXe7jM9u72Py9d35l7MP9PLj-4uz00vaCSVnKlptmrr3vkFslWyg6WsugYkeFAeFvPXAjBa90sZj3XPthGlb7pkQnIOoj8mrve6U4o8F82yHkDvc7dyIccmWA5OilkKt6Mu_0Ku4pLFst1JCay21uqe2boc2jD6Wf-lWUXsqasWUMbUp1Mk_qHJ6HEIXR_Sh1A8GXh8MFGbG63nrlpztxedPhyzbs12KOSf0dkphcOnGMrBr9HYfvS3R2zV6u5p7cWtuaQfs_0zcZV0AvgdyaY1bTPfu_6_6G4ujtnY</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Zheng, Sen</creator><creator>Sonomoto, Kenji</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria</title><author>Zheng, Sen ; Sonomoto, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-5b8943dff4eeb76404d326015d07207e2bf01985d789fe3d28a59bb2f15522053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Sen</au><au>Sonomoto, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>102</volume><issue>10</issue><spage>4243</spage><epage>4253</epage><pages>4243-4253</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resistant bacteria such as methicillin-resistant
Staphylococcus aureus
and vancomycin-resistant
Enterococcus
. As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29560521</pmid><doi>10.1007/s00253-018-8917-5</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2018-05, Vol.102 (10), p.4243-4253 |
| issn | 0175-7598 1432-0614 |
| language | eng |
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| source | ABI/INFORM Global; Springer Link |
| subjects | Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotic resistance Antibiotics Antimicrobial peptides Bacteria Bacteriocins Bacteriocins - genetics Bacteriocins - metabolism Bacteriocins - pharmacology Biomedical and Life Sciences Biosynthesis Biotechnology Chemistry, Pharmaceutical - trends Drug resistance Gram-positive bacteria Gram-Positive Bacteria - physiology Health aspects Life Sciences Membrane proteins Membrane Transport Proteins - metabolism Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Genetics and Genomics Microbiology Mini-Review Peptides Proteins Secretion Staphylococcus infections Vancomycin |
| title | Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria |
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