Personalized vaccines for cancer immunotherapy

Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign and constitute ideal cancer vaccine targets. Every tumor has its own unique composition of mutations, with only a small f...

Full description

Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2018-03, Vol.359 (6382), p.1355-1360
Main Authors:	Sahin, Ugur, Türeci, Özlem
Format:	Article
Language:	English
Subjects:	Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer Vaccines - genetics Cancer Vaccines - therapeutic use Humans Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Immunotherapy - methods Mutation Neoplasms - genetics Neoplasms - therapy Precision Medicine - methods
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!