Modification of apparent intracerebral hematoma volume on T2∗-weighted images during normobaric oxygen therapy may contribute to false diagnosis

•This study suggests that T2∗-weighted MRI used to diagnose intracerebral hematoma (ICH) can be impaired by normobaric oxygen therapy (NBO).•The false decrease of the hematoma volume after NBO can lead to an inaccurate diagnosis, particularly for hematoma growth evaluation.•Although this result has...

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Published in:Journal of clinical neuroscience 2018-06, Vol.52, p.105-108
Main Authors: Goulay, Romain, Drieu, Antoine, Di Palma, Camille, Pro-Sistiaga, Palma, Delcroix, Nicolas, Chazalviel, Laurent, Saulnier, Romaric, Gakuba, Clément, Goursaud, Suzanne, Young, Allan R., Gauberti, Maxime, Orset, Cyrille, Emery, Evelyne, Vivien, Denis, Gaberel, Thomas
Format: Article
Language:English
Subjects:
Animals
Cerebral Hemorrhage - diagnostic imaging
Diagnostic Errors
Hematoma - diagnostic imaging
Intracerebral hemorrhage
Magnetic resonance imaging
Magnetic Resonance Imaging - standards
Oxygen inhalation therapy
Oxygen Inhalation Therapy - adverse effects
Swine
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Summary:•This study suggests that T2∗-weighted MRI used to diagnose intracerebral hematoma (ICH) can be impaired by normobaric oxygen therapy (NBO).•The false decrease of the hematoma volume after NBO can lead to an inaccurate diagnosis, particularly for hematoma growth evaluation.•Although this result has to be confirmed in human, we recommend to avoid NBO during T2∗-weighted MRI acquisition for ICH imaging. It was previously reported that normobaric oxygen therapy (NBO) significantly affected T2∗-weighted imaging in a mouse model of intracerebral hemorrhage (ICH). However, it is unclear whether a similar phenomenon exists in large volume ICH as seen in human pathology. We investigated the effects of NBO on T2∗-weighted images in a pig model of ICH. Our data show that NBO makes disappear a peripheral crown of the hematoma, which in turn decreases the apparent volume of ICH by 18%. We hypothesized that this result could be translated to ICH in human, and subsequently could lead to inaccurate diagnostic.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2018.01.046