Necroptosis in development and diseases

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions. Modulating the activation of RIPK1 by ubiquitination...

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Bibliographic Details
Published in:Genes & development 2018-03, Vol.32 (5-6), p.327-340
Main Authors: Shan, Bing, Pan, Heling, Najafov, Ayaz, Yuan, Junying
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Cell Death - physiology
Disease
Growth and Development - genetics
Growth and Development - physiology
Mutation - genetics
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors
Receptor-Interacting Protein Serine-Threonine Kinases - genetics
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Review
Signal Transduction
Tumor Necrosis Factor-alpha - metabolism
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