Value of super(123)I-IMT SPECT for diagnosis of recurrent non-astrocytic intracranial tumours

The value of single-photon emission tomography (SPECT) using iodine-123-alpha-methyl-tyrosine (IMT) for the diagnosis of recurrent or residual gliomas is welt established. In the current study we investigated whether IMT-SPECT could also be useful in the follow-up of brain metastases and other intra...

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Bibliographic Details
Published in:Neuroradiology 2005-01, Vol.47 (1), p.18-26
Main Authors: Plotkin, M, Amthauer, H, Eisenacher, J, Wurm, R, Michel, R, Wust, P, Stockhammer, F, Roettgen, R, Gutberlet, M, Ruf, J, Felix, R
Format: Article
Language:English
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Summary:The value of single-photon emission tomography (SPECT) using iodine-123-alpha-methyl-tyrosine (IMT) for the diagnosis of recurrent or residual gliomas is welt established. In the current study we investigated whether IMT-SPECT could also be useful in the follow-up of brain metastases and other intracranial tumours of non-astrocytic origin. The study included 22 patients with suspected recurrent intracranial tumours of non-astrocytic origin (12 brain metastases, one supratentorial primitive neuroendocrine tumour (PNET), one rhabdoid tumour, two clivus chordomas, three ependymomas, two pituitary tumours, one anaplastic meningioma) who had previously been treated by surgery and/or radio/chemotherapy, SPECT results were correlated with clinical and MRI follow-up data. The study was true positive in 13 patients, true negative in five, false positive in one and false negative in three patients. Notably, all false negative findings were
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-004-1288-x