Intensity of surveillance for hepatocellular carcinoma determines survival in patients at risk in a hepatitis B‐endemic area

Summary Background Data are insufficient regarding the survival benefit of surveillance for hepatocellular carcinoma (HCC). Aim To investigate the effectiveness of HCC surveillance in a hepatitis B‐endemic population. Methods This retrospective cohort study included 1402 consecutive patients who wer...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2018-06, Vol.47 (11), p.1490-1501
Main Authors: Kim, H. Y., Nam, J. Y., Lee, J.‐H., Lee, H. A., Chang, Y., Lee, H. Y., Cho, H., Lee, D. H., Cho, Y. Y., Cho, E. J., Yu, S. J., Lee, J. M., Kim, Y. J., Yoon, J.‐H.
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - mortality
Cirrhosis
Early Diagnosis
Female
Health risk assessment
Hepatitis
Hepatitis B
Hepatitis B - diagnosis
Hepatitis B - mortality
Hepatocellular carcinoma
Humans
Lead
Liver cancer
Liver cirrhosis
Liver Cirrhosis - diagnosis
Liver Cirrhosis - mortality
Liver Neoplasms - diagnosis
Liver Neoplasms - mortality
Middle Aged
Mortality
Patients
Population Surveillance - methods
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Surveillance
Survival
Survival Rate - trends
Ultrasound
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Summary:Summary Background Data are insufficient regarding the survival benefit of surveillance for hepatocellular carcinoma (HCC). Aim To investigate the effectiveness of HCC surveillance in a hepatitis B‐endemic population. Methods This retrospective cohort study included 1402 consecutive patients who were newly diagnosed with HCC between 2005 and 2012 at a single tertiary hospital in Korea. The primary endpoint was overall survival. Lead‐time and length‐time biases were adjusted (sojourn time = 140 days) and sensitivity analyses were performed. Results The most common aetiology was hepatitis B (80.4%). Cirrhosis was present in 78.2%. HCC was diagnosed during regular surveillance (defined as mean interval of ultrasonography
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.14623