Fish skin as a model membrane: structure and characteristics

Objectives Synthetic and cell‐based membranes are frequently used during drug formulation development for the assessment of drug availability. However, most of the currently used membranes do not mimic mucosal membranes well, especially the aqueous mucous layer of the membranes. In this study we eva...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2009-01, Vol.61 (1), p.121-124
Main Authors: Konrádsdóttir, Fífa, Loftsson, Thorsteinn, Sigfússon, Sigurdur Dadi
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
Algorithms
Animals
Benzocaine - pharmacokinetics
beta-Cyclodextrins - pharmacokinetics
Catfishes
Diethylstilbestrol - pharmacokinetics
Diffusion
Hydrocortisone - pharmacokinetics
In Vitro Techniques
Kinetics
Lidocaine - pharmacokinetics
Membranes - anatomy & histology
Membranes - metabolism
Models, Biological
mucosa
mucus
Naproxen - pharmacokinetics
Nitrates - pharmacokinetics
Permeability
permeation
Picrates - pharmacokinetics
Skin - anatomy & histology
Skin - metabolism
Skin Absorption
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Summary:Objectives Synthetic and cell‐based membranes are frequently used during drug formulation development for the assessment of drug availability. However, most of the currently used membranes do not mimic mucosal membranes well, especially the aqueous mucous layer of the membranes. In this study we evaluated catfish (Anarichas lupus L) skin as a model membrane. Method Permeation of hydrocortisone, lidocaine hydrochloride, benzocaine, diethyl‐stilbestrol, naproxen, picric acid and sodium nitrate through skin from a freshly caught catfish was determined in Franz diffusion cells. Key findings Both lipophilic and hydrophilic molecules permeate through catfish skin via hydrated channels or aqueous pores. No correlation was observed between the octanol/water partition coefficient of the permeating molecules and their permeability coefficient through the skin. Permeation through catfish skin was found to be diffusion controlled. Conclusions The results suggest that permeation through the fish skin proceeds via a diffusion‐controlled process, a process that is similar to drug permeation through the aqueous mucous layer of a mucosal membrane. In addition, the fish skin, with its collagen matrix structure, appears to possess similar properties to the eye sclera.
ISSN:0022-3573
2042-7158
DOI:10.1211/jpp.61.01.0017