Neural Correlates of Audiovisual Sensory Integration

• Published in: Neuropsychology 2018-03, Vol.32 (3), p.329-336
• Main Authors: Huang, Jia, Reinders, Antje A. T. S., Wang, Ya, Xu, Ting, Zeng, Ya-wei, Li, Ke, Handley, Rowena, Cheung, Eric F. C., Chan, Raymond C. K., Dazzan, Paola
• Format: Article
• Language: English
• Subjects: Auditory Perception; Female; Human; Male; Neuroimaging; Occipital Lobe; Parietal Lobe; Sensory Integration; Test Construction; Visual Perception
• ISSN: 0894-4105; 1931-1559
• DOI: 10.1037/neu0000393

Objective: The present study aimed to investigate the neural basis of information matching during sensory integration using a spatial-temporal matching task in healthy individuals. Method: A total of 37 healthy participants were recruited to match spatial dots with an auditory tone sequence in a 3T GE Discovery MR750 scanner. In addition, they were examined with the sensory integration subscale of the Cambridge Neurological Inventory. Results: We found that the bilateral occipital-parietal conjunction cortex and the precentral frontal gyrus were activated during the matching condition rather than in the nonmatching condition. Activation of the occipital-parietal conjunction cortex was associated with integration of information across visual and auditory modalities, whereas activation of the precentral frontal gyrus was associated with decision making of movements. In addition, activation of the left superior frontal gyrus was associated with scores on the sensory integration subscale of the Cambridge Neurological Inventory. Conclusions: These findings suggest that the bilateral occipital-parietal conjunction cortex is responsible for matching information input from multiple modalities during audiovisual sensory integration. General Scientific Summary This study aimed to examine information matching during audiovisual sensory integration with a spatial-temporal matching task using functional imaging in healthy volunteers. The findings suggest that the bilateral occipital-parietal conjunction cortex is responsible for matching information input from multiple modalities during audiovisual sensory integration. These findings have clinical implications for the understanding of the underlying neural mechanism of sensory integration in schizophrenia and autism spectrum disorders.