Curative Resection for Hilar Cholangiocarcinoma: Single-Center Experience with Long-Term Follow-Up

Hilar cholangiocarcinoma (HC), also known as Klatskin tumor, is a relatively rare neoplasm which originates from the biliary confluence or the main hepatic ducts and is characterized by poor response to either chemotherapy or radiotherapy; the only possible curative treatment is radical surgery ofte...

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Bibliographic Details
Published in:The American surgeon 2018-01, Vol.84 (1), p.9-10
Main Authors: Feo, Claudio F., Ginesu, Giorgio C., Barmina, Michele, Pinna, Antonio, Scanu, Antonio M., Cossu, Maria L., Fancellu, Alessandro, Porcu, Alberto
Format: Article
Language:English
Subjects:
Chemotherapy
Cholangiocarcinoma
Diagnostic software
Diagnostic systems
Liver
Medical prognosis
Morbidity
Mortality
Patients
Radiation therapy
Surgery
Surgical outcomes
Surgical techniques
Systematic review
Veins & arteries
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Summary:Hilar cholangiocarcinoma (HC), also known as Klatskin tumor, is a relatively rare neoplasm which originates from the biliary confluence or the main hepatic ducts and is characterized by poor response to either chemotherapy or radiotherapy; the only possible curative treatment is radical surgery often through major liver resections, with relevant postoperative morbidity and mortality.1 We report here our experience with a series of patients who underwent curative resection for HC, and we have analyzed the outcomes after a long-term follow-up. Surgical resection with negative margins is often obtained with major liver resections, characterized by decreasing morbidity and mortality in recent times.2 Preoperative biliary drainage, used in 12 cases in our cohort, has been suggested to reduce bilirubin level in jaundice patients and improve the function of the future liver remnant; however, results are still controversial. 3 PVE was used in two cases in our series to improve the volume of the future liver remnant; both patients had an uneventful postoperative course. [...]surgical outcomes for HC have improved over time as a result of aggressive surgery and progress in surgical techniques, perioperative management, and diagnostic tools.
ISSN:0003-1348
1555-9823
DOI:10.1177/000313481808400106