Comparative imaging of a slow-release starch excipient tablet: Evidence of membrane formation

A controlled release excipient made of chemically modified high-amylose starch (HAS) has been used to explore the surface membrane responsible for the slow release characteristics. Using scanning electron microscopy (SEM) and X-ray computed microtomography (CMT), the radial and axial surfaces of dry...

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Bibliographic Details
Published in:Carbohydrate polymers 2007-08, Vol.70 (1), p.61-67
Main Authors: Chauve, Grégory, Ravenelle, François, Marchessault, Robert H.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Controlled-release
Exact sciences and technology
Excipient
General pharmacology
High amylose starch
Hydrogel
Imaging
Medical sciences
Membrane
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Porosity
Scanning electron microscopy
Slow-release
Starch and polysaccharides
Tomography
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Summary:A controlled release excipient made of chemically modified high-amylose starch (HAS) has been used to explore the surface membrane responsible for the slow release characteristics. Using scanning electron microscopy (SEM) and X-ray computed microtomography (CMT), the radial and axial surfaces of dry, swollen and freeze-dried sections observed were arranged in concentric domains. The presence of water enhances contrast in CMT imaging of the swollen tablet compared to the non-hydrated state. Freeze-dried SEM images showed a twin domain structure, thus defining membrane thickness. CMT quantified the average global porosity of the dry and swollen domains. The bird’s eye view of the latter defined a central-core with high contrast and 34% porosity while the average global porosity was 19% and the dry porosity was 10%. The overall membrane after 15 min swelling is best described as concentric hydrogel domains.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2007.03.004