Mapping QTL for production traits in segregating Piétrain pig populations using genome‐wide association study results of F2 crosses

Summary In this study, genome‐wide association study (GWAS) results of porcine F2 crosses were used to map QTL in outcross Piétrain populations. For this purpose, two F2 crosses (Piétrain × Meishan, n = 304; Piétrain × Wild Boar, n = 291) were genotyped with the PorcineSNP60v2 BeadChip and phenotype...

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Bibliographic Details
Published in:Animal genetics 2018-08, Vol.49 (4), p.317-320
Main Authors: Schmid, M., Maushammer, M., Preuß, S., Bennewitz, J.
Format: Article
Language:English
Subjects:
Animal models
Animal populations
Gene mapping
Genetic crosses
Genome-wide association studies
Genomes
Hogs
Livestock breeding
Mapping
mapping power
Phenotypes
pooled F2 cross
Populations
Progeny
QTL core regions
QTL validation
Quantitative trait loci
Single-nucleotide polymorphism
SNP validation
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Summary:Summary In this study, genome‐wide association study (GWAS) results of porcine F2 crosses were used to map QTL in outcross Piétrain populations. For this purpose, two F2 crosses (Piétrain × Meishan, n = 304; Piétrain × Wild Boar, n = 291) were genotyped with the PorcineSNP60v2 BeadChip and phenotyped for the dressing yield, carcass length, daily gain and drip loss traits. GWASs were conducted in the pooled F2 cross applying single marker mixed linear models. For the investigated traits, between two and five (in total 15) QTL core regions, spanning 250 segregating SNPs around a significant trait‐associated peak SNP, were identified. The SNPs within the QTL core regions were subsequently tested for trait association in two outcross Piétrain populations consisting of 771 progeny‐tested boars and 210 sows with their own performance records. In the sow (boar) dataset, five (eight) of the 15 mapped QTL were validated. Hence, many QTL mapped in the F2 crosses (with Piétrain as a common founder breed) are still segregating in the current Piétrain breed. This confirms the usefulness of existing F2 crosses for mapping QTL that are still segregating in the recent founder breed generation. The approach utilizes the high power of an F2 cross to map QTL in a breeding population for which it is not guaranteed that they would be found using a GWAS in this population.
ISSN:0268-9146
1365-2052
DOI:10.1111/age.12663