The degeneration of adjacent intervertebral discs negatively influence union rate of osteoporotic vertebral fracture: A multicenter cohort study

• Published in: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2018-07, Vol.23 (4), p.627-634
• Main Authors: Rahmani, Mohammad Suhrab, Takahashi, Shinji, Hoshino, Masatoshi, Takayama, Kazushi, Sasaoka, Ryuichi, Tsujio, Tadao, Yasuda, Hiroyuki, Kanematsu, Fumiaki, Kono, Hiroshi, Toyoda, Hiromitsu, Nakamura, Hiroaki
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Cohort Studies; Disease Progression; Female; Fracture Healing - physiology; Humans; Intervertebral Disc - diagnostic imaging; Intervertebral Disc - pathology; Intervertebral Disc Degeneration - diagnostic imaging; Intervertebral Disc Degeneration - pathology; Intervertebral Disc Degeneration - surgery; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - physiopathology; Magnetic Resonance Imaging - methods; Male; Osteoporotic Fractures - diagnostic imaging; Osteoporotic Fractures - pathology; Osteoporotic Fractures - surgery; Prognosis; Retrospective Studies; Risk Assessment; Spinal Fractures - diagnostic imaging; Spinal Fractures - pathology; Spinal Fractures - surgery; Tomography, X-Ray Computed - methods
• ISSN: 0949-2658; 1436-2023
• DOI: 10.1016/j.jos.2018.03.008

With the increasing aging population in developed countries, there has been an associated increased prevalence of osteoporotic vertebral fracture (OVF). Many previous reports have attempted to predict the risk of delayed union associated with OVF. However, the role of endplate failure and the degeneration of adjacent intervertebral discs, and their association with delayed union has received little attention. The aim of this study was to evaluate the endplate fracture and disc degeneration rank as risk factors for delayed union. Two hundred and eighteen consecutive patients with fresh OVF were enrolled in the study. MRI and X–ray were performed at the time of enrollment and at the 6 months follow-up. The MR images were used to assess the degeneration grade of adjacent intervertebral discs (using the modified Pfirrmann grading system), and endplate failure. Supine and weight-bearing radiographs were used to define angular motion and compression ratio of the anterior vertebral body wall. A total of 139 patients (112 female, 27 male) completed the 6 month follow-up (a 65.1% follow-up rate). The study revealed 27 cases of delayed union (19.4%). A healthier adjacent caudal disc with low grade degeneration was found to be associated with an increased risk of delayed union (P = 0.008). Bi-endplate injury and significant compression of the anterior vertebral body wall were significantly associated with delayed union (P = 0.019, and P = 0.001 respectively). Rapid progression of the adjacent cranial disc degeneration was observed at the end of the 6 month follow-up period (P = 0.001). Modified Pfirrmann grading system revealed that a healthier adjacent intervertebral disc at the caudal level and bi-endplate fracture were significantly associated with an increased risk of delayed union. These findings may influence the management strategy for patients with OVF.