Effects of continuous positive airway pressure on cardiovascular biomarkers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials

• Published in: Sleep & breathing 2019-03, Vol.23 (1), p.77-86
• Main Authors: Ning, Yu, Zhang, Tian-Song, Wen, Wan-Wan, Li, Kun, Yang, Yun-Xiao, Qin, Yan-Wen, Zhang, Hui-Na, Du, Yun-Hui, Li, Lin-Yi, Yang, Song, Yang, Yun-Yun, Zhu, Miao-Miao, Jiao, Xiao-Lu, Zhang, Yan, Zhang, Ming, Wei, Yong-Xiang
• Format: Article
• Language: English
• Subjects: Apnea; Biomarkers; Biomarkers - metabolism; C-reactive protein; Cardiovascular diseases; Cardiovascular System - metabolism; Cardiovascular System - physiopathology; Clinical trials; Continuous Positive Airway Pressure; Dentistry; Humans; Inflammation; Interleukin 6; Internal Medicine; Medicine; Medicine & Public Health; Meta-analysis; Neurology; Otorhinolaryngology; Patients; Pediatrics; Pneumology/Respiratory System; Polysomnography; Pressure; Randomized Controlled Trials as Topic; Respiratory tract; Sleep; Sleep apnea; Sleep Apnea, Obstructive - therapy; Sleep Breathing Physiology and Disorders • Original Article; Sleep disorders; Systematic review; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vascular Stiffness - physiology
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-018-1662-2

Purpose Obstructive sleep apnea (OSA) is associated with increased levels of systemic inflammatory markers, increased arterial stiffness, and endothelial dysfunction, which may lead to increased cardiovascular risk. We aimed to quantify the effects of continuous positive airway pressure (CPAP) on cardiovascular biomarkers and to establish predictors of response to CPAP. Methods We searched PubMed and the Cochrane Library from inception to May 31, 2017. Randomized controlled trials (RCTs) assessing the efficacy of CPAP on high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor- alpha (TNF-α), augmentation index (AIx), pulse wave velocity (PWV), and flow-mediated dilatation (FMD) in patients with OSA were selected by consensus. Results We included 15 RCTs comprising 1090 patients in the meta-analysis. The pooled standard mean difference (SMD) of effect of CPAP on hs-CRP was − 0.64 (95% confidence interval (CI) − 1.19 to − 0.09; P  = 0.02). CPAP was associated with a reduction in AIx of 1.53% (95% CI, 0.80 to 2.26%; P