Acute toxicity of sodium arsenite in a complex food matrix

• Published in: Food and chemical toxicology 2007-09, Vol.45 (9), p.1606-1613
• Main Authors: Sprando, R.L., Collins, T.F.X., Black, T., Olejnik, N., Ramos-Valle, M., Ruggles, D.
• Format: Article
• Language: English
• Subjects: Administration, Oral; animal models; Animals; Arsenites - administration & dosage; Arsenites - toxicity; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Complex food matrix; cream; dietary exposure; Dietary Fats - pharmacology; Dose-Response Relationship, Drug; embryonic mortality; embryotoxicity; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - toxicity; Female; females; Fetal Resorption - chemically induced; Fetal Resorption - pathology; fetotoxicity; Fetus; Fetus - drug effects; Fetus - embryology; Food Contamination; food matrix; Gestational Age; inorganic acids; Male; Male rat; males; Medical sciences; Metals and various inorganic compounds; mortality; Non-pregnant female rat; Pregnancy; pregnancy outcome; Pregnant female rat; Rat; Rats; Rats, Sprague-Dawley; Sodium arsenite; Sodium Compounds - administration & dosage; Sodium Compounds - toxicity; Survival Rate; toxicity testing; Toxicity Tests, Acute; Toxicology; Water - pharmacology
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2007.02.026

Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0 mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0 mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0 mg/kg As in deionized water (41 mg/kg As–water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0 mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41 mg/kg As–water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41 mg/kg As–water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410 mg/kg) was administered in HH however, at lower doses (41 mg/kg), HH reduced acute As oral toxicity in the female and developing fetus.